Inhibitors of Intestinal Motility

Substances Affecting Intestinal Motility

Gastrin primarily stimulates gastric acid secretion and has minimal effects on intestinal motility, according to the American Gastroenterological Association 1
Cholecystokinin (CCK) stimulates rather than inhibits intestinal motility, primarily functioning to stimulate gallbladder contraction and pancreatic enzyme secretion, as stated by the American Gastroenterological Association 1
Motilin acts as a prokinetic agent that stimulates intestinal motility, with motilin receptor agonists like erythromycin used to enhance gut motility in patients with gastrointestinal motility disorders, as recommended by the European Society of Gastrointestinal Motility 2
Serotonin (5-HT) generally promotes intestinal motility rather than inhibiting it, with 5-HT4 receptor agonists like prucalopride used as prokinetic agents to stimulate colonic peristalsis and enhance bowel motility, according to the European Society of Gastrointestinal Motility 2