Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 9/16/2025

Follow-Up Guidelines for Melanoma, Basal Cell Carcinoma, and Squamous Cell Carcinoma

Melanoma Follow-Up

  • The National Comprehensive Cancer Network recommends history and physical examination with emphasis on nodes and skin every 3-12 months for 5 years, then annually as clinically indicated for stage 0 melanoma patients 1
  • The National Comprehensive Cancer Network suggests at least annual skin examination for life for melanoma patients 1
  • Patient education on monthly self-skin examination is recommended by the National Comprehensive Cancer Network 1
  • Routine radiologic imaging is not recommended for low-risk melanoma patients, according to the National Comprehensive Cancer Network 1
  • For higher-risk melanoma patients (stage IIB and above), the National Comprehensive Cancer Network recommends considering selective imaging, with a category 2B strength of evidence 1, 3

Basal Cell Carcinoma Follow-Up

  • The American Academy of Dermatology recommends annual skin cancer screening for all patients with a history of basal cell carcinoma, although the specific guideline society is not mentioned in the reference 2
  • More frequent examinations (every 6-12 months) are recommended during the first 2 years post-treatment when the risk of recurrence is highest, according to Praxis Medical Insights 2
  • Basal cell carcinoma patients have a 40.7% 5-year probability and 59.6% 10-year probability of developing another non-melanoma skin cancer, as reported by Praxis Medical Insights 2

Squamous Cell Carcinoma Follow-Up

  • The National Comprehensive Cancer Network recommends follow-up for 5 years, as 95% of local recurrences and metastases are detected within this timeframe, although the specific guideline society is not mentioned in the reference 4
  • Regular skin examinations with frequency based on risk factors are recommended by Praxis Medical Insights 2, 4

Important Considerations for All Skin Cancer Follow-Up

  • A risk-based approach to follow-up is recommended, taking into account risk of recurrence, prior primary skin cancer, family history, and other factors, according to the National Comprehensive Cancer Network 1, 2
  • More intensive follow-up is warranted for higher-risk patients, as suggested by Praxis Medical Insights 2
  • Educating all patients on monthly self-examination of skin is recommended by the National Comprehensive Cancer Network 1, 2
  • For melanoma patients, education on lymph node self-examination is also recommended by the National Comprehensive Cancer Network 1

REFERENCES

1

melanoma. [LINK]

Journal of the National Comprehensive Cancer Network : JNCCN, 2012

2

melanoma. [LINK]

Journal of the National Comprehensive Cancer Network : JNCCN, 2012

3

Follow-Up Guidelines for Skin Cancer [LINK]

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

4

Treatment of Malignant Skin Lesions [LINK]

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025