Tigecycline Dosing Considerations

Clinical Guidelines for Severe Infections

• For severe infections like hospital-acquired pneumonia (HAP) in patients with normal hepatic function, the American College of Physicians recommends higher doses (200 mg loading followed by 100 mg every 12 hours) 1
• Patients with severe hepatic impairment receiving tigecycline for infections such as multidrug-resistant Acinetobacter baumannii should be considered for combination therapy with another active agent if possible, as recommended by the Infectious Diseases Society of America 2