Adderall Equivalent Dosing to Lisdexamfetamine 70 mg

Pharmacokinetic Basis for Conversion

Lisdexamfetamine is a prodrug that is enzymatically converted to dextroamphetamine after oral ingestion, with the l-lysine amino acid cleaved off through rate-limited hydrolysis in the blood, according to the American Journal of Obstetrics and Gynecology 1

The American Academy of Child and Adolescent Psychiatry recommends starting with Adderall XR 30 mg once daily in the morning as the initial equivalent dose when converting from lisdexamfetamine 70 mg, with a potential range up to 40 mg total daily dose 2, 3, 4
The maximum recommended total daily dose for Adderall is 50 mg for adults, though clinical practice sometimes uses up to 40 mg as a practical upper limit when given in multiple doses throughout the day, as suggested by the American Journal of Obstetrics and Gynecology and the Journal of the American Academy of Child and Adolescent Psychiatry 2, 4
If using immediate-release Adderall, begin with 10-15 mg twice daily (20-30 mg total daily dose) and titrate upward in 5 mg increments weekly based on response, according to the Journal of the American Academy of Child and Adolescent Psychiatry 4

Monitor closely for breakthrough symptoms in the late afternoon/evening and for side effects including insomnia, decreased appetite, increased blood pressure and heart rate during the conversion period, as recommended by the American Journal of Obstetrics and Gynecology and the Journal of the American Academy of Child and Adolescent Psychiatry 2, 4
Titrate the final Adderall dose based on clinical response rather than strict mathematical conversion, as individual patient factors affect optimal dosing, according to the Journal of the American Academy of Child and Adolescent Psychiatry 4