Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 9/8/2025

Treatment Protocol for Erectile Dysfunction with Acoustic Radio Wave Therapy

Current Position of LiSWT in ED Treatment Algorithm

  • Standard first-line treatments for erectile dysfunction include FDA-approved oral PDE5 inhibitors, which should be offered with proper dosing instructions and titration before considering alternative therapies, as recommended by The Journal of Urology 2, 3
  • The European Association of Urology guidelines (2025) recommend that LiSWT may be used in men with mild vasculogenic ED (weak recommendation) 1
  • LiSWT is considered an innovative treatment modality that requires further large-scale, placebo-controlled studies for full clinical validation, according to European Urology 1

Important Clinical Considerations

  • A thorough medical, sexual, and psychosocial history is essential, as stated by The Journal of Urology 4
  • Physical examination and selective laboratory testing should be completed, including morning total testosterone, as recommended by The Journal of Urology and European Urology 2, 1
  • ED may be a risk marker for underlying cardiovascular disease that requires evaluation, according to The Journal of Urology and Mayo Clinic Proceedings 2, 5

Combination Therapy and Treatment Decisions

  • LiSWT may be more effective when combined with other treatments, such as PDE5 inhibitors, vacuum erection devices, or daily tadalafil, as suggested by European Urology 1
  • Psychosexual counseling should be considered to address psychological factors and improve treatment adherence, as recommended by The Journal of Urology and Praxis Medical Insights 2, 6
  • Treatment decisions should be made jointly by the physician, patient, and when possible, the partner, considering preferences, expectations, and the physician's judgment, according to The Journal of Urology 7