Endometriosis Prevalence and Diagnosis

Epidemiological Data

Endometriosis affects approximately 2% to 10% of women of childbearing age worldwide, translating to approximately 176 million women globally, with a diagnosed prevalence of up to 10% in reproductive-age women in the United States, according to the American College of Obstetricians and Gynecologists 1
Endometriosis is characterized by the presence of nonmalignant endometrium-like tissue (glands and/or stroma) outside the uterus, as defined by the American Heart Association 2, 3

The condition is typically diagnosed during reproductive years, identifying an at-risk group in early adulthood, as reported by the American Stroke Association 4, 5

Endometriosis is associated with hypercholesterolemia, hypertension, hypertensive disorders of pregnancy, and increased cardiovascular disease risk, as found by the American Heart Association 2, 3
Recent high-quality observational studies have consistently found a 16% to 34% increased risk of stroke among those with endometriosis, according to the American Stroke Association 4, 5, 6

Screening for a history of endometriosis is reasonable to inform the risk of stroke, as recommended by the American Stroke Association 4, 5, 6
In individuals with endometriosis, vascular risk factor evaluation and modification are reasonable to reduce the risk of stroke, as suggested by the American Stroke Association 4, 5, 6

The World Endometriosis Society recommends a classification toolbox that includes the revised American Society for Reproductive Medicine staging system and, where appropriate, the Enzian and Endometriosis Fertility Index staging systems, as published in Human Reproduction Update 1