Management of Hiccups and Nausea After Lorazepam
Understanding the Association
- The American Academy of Pediatrics recommends a typical dose of chlorpromazine: 25-50mg orally every 6 hours as needed for hiccups 1
Management of Hiccups
- The Mayo Clinic suggests baclofen as a treatment option for persistent hiccups, with a starting dose of 5-10mg three times daily 2
- The Journal of the National Comprehensive Cancer Network recommends metoclopramide 10-20mg orally or IV every 4-6 hours for hiccups 3
Management of Nausea
- The National Comprehensive Cancer Network recommends ondansetron 8mg orally or 4mg IV for medication-induced nausea 4
- The Mayo Clinic suggests dexamethasone 4-8mg orally to augment antiemetic therapy 2
- The Journal of the National Comprehensive Cancer Network recommends promethazine 25mg orally or rectally every 6 hours for nausea 3
Comprehensive Approach
- The National Comprehensive Cancer Network recommends treating nausea with ondansetron or prochlorperazine 4
- The European Heart Journal suggests divided doses of lorazepam may reduce the incidence of side effects 6
Special Considerations
- The American Academy of Pediatrics warns to monitor for sedation when using chlorpromazine, especially if the patient has already received lorazepam 1
- The American Academy of Pediatrics advises to be aware of potential QT prolongation with both ondansetron and chlorpromazine, particularly in patients with cardiac risk factors 1
Prevention for Future Use
- The National Comprehensive Cancer Network recommends pre-medication with ondansetron before lorazepam administration to prevent nausea 4