Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) Diagnosis and Clinical Features

Clinical Presentation and Diagnostic Considerations

• The European Hematology Association notes that CIDP typically presents with a proximal-predominant pattern of weakness, contrasting with most other neuropathies which begin distally in a "stocking-glove" distribution 1
• The American Diabetes Association recommends that assessment should include careful history and evaluation of both proximal and distal muscle strength, as well as tests of small-fiber function and large-fiber function 2
• Deep tendon reflexes are typically reduced or absent in proportion to sensory loss, according to the European Hematology Association 1
• Evaluation should include tests of small-fiber function (pinprick and temperature sensation) and large-fiber function (reflexes, vibration perception), as suggested by the American Diabetes Association 2