Apixaban and Hypotension

Clinical Trial Evidence

• The ARISTOTLE trial, which compared apixaban to warfarin in patients with nonvalvular atrial fibrillation, did not report hypotension as a significant adverse effect 1

Special Considerations

• Patients with renal dysfunction may have higher blood levels and longer half-lives of apixaban due to reduced clearance, potentially increasing the risk of adverse effects, though hypotension is not specifically mentioned 2
• Elderly patients (>75 years) may be more susceptible to adverse effects from drug interactions with apixaban, according to the American College of Cardiology 3