Managing a Missed Dose of Tezspire (Tezepelumab)

Rationale for Recommendation

There are no specific evidence-based guidelines on dose adjustments for missed Tezspire doses, similar to the lack of evidence-based guidelines for allergen immunotherapy 1

Shifting the entire schedule by 5 days would create unnecessary complexity in the medication regimen and potentially lead to further adherence issues 2

For doses missed by less than 7 days, administer the missed dose as soon as possible and continue with the original dosing schedule, as recommended by the American Academy of Allergy, Asthma, and Immunology 1, 3
For doses missed by less than 7 days, no dose adjustment is necessary, and the patient should maintain the same future dates, according to the European Society of Cardiology 4

The approach to managing missed Tezspire doses is similar to recommendations for other injectable biologics, such as non-vitamin K antagonist oral anticoagulants (NOACs), where the European Heart Society recommends taking the missed dose and continuing the regular schedule 4
The approach is also consistent with principles applied to contraceptives, where the Centers for Disease Control and Prevention recommend taking the missed dose and continuing the regular schedule for missed doses <48 hours 5

Encourage patients to set reminders for future doses to improve adherence, as suggested by the Infectious Diseases Society of America 6