Allopurinol Dosage in Renal Impairment

Dosing Considerations

• A dose reduction of 50% is recommended in patients with renal insufficiency due to prolonged oxypurinol half-life, as suggested by the Journal of Clinical Oncology 1

Pharmacokinetics in Renal Impairment

• In patients with moderate to severe renal impairment, oxypurinol clearance is dramatically reduced, with apparent clearance decreasing from 1.8 L/h in normal renal function to 0.6 L/h in mild impairment, 0.3 L/h in moderate impairment, and 0.18 L/h in severe impairment, according to the Journal of Clinical Oncology 1