Platelet-Rich Plasma Therapy

Adverse Effects

The most frequently reported side effects of PRP therapy are temporary pain or discomfort during the injection process, with temporary swelling and bruising also common, particularly in delicate areas like the periorbital region 1
Pain during injection is the primary complaint, although PRP is generally better tolerated than some alternatives, such as minoxidil, due to injection-related pain 1

The entire process of PRP therapy, from blood collection to administration, presents opportunities for microbial contamination, highlighting the need for strict adherence to aseptic technique and standardized protocols 1
The use of PRP therapy requires caution, particularly in delicate areas like the periorbital region, due to the thin and delicate skin in this region 1
The International Society on Thrombosis and Haemostasis (ISTH) guidelines highlight the poor standardization and variability in PRP preparation methods, which complicates its application in procedures like breast augmentation 2
The American College of Periodontology does not support the use of PRP in cosmetic breast augmentation due to lack of evidence 1

PRP has shown promise in facial skin rejuvenation, lip rejuvenation, perioral wrinkle reduction, hair restoration, and wound healing, but not in breast augmentation 1
PRP increases collagen production, improving skin elasticity and firmness, and demonstrates efficacy for fine wrinkling and color homogeneity in photoaged skin 1
PRP shows potential for treating periorbital hyperpigmentation (POH) and crow's feet, with significant improvement in periocular wrinkles through increased skin thickness 1
PRP makes lip color more vivid, reduces superficial perioral wrinkles, and provides biostimulation with natural-looking outcomes, with typical treatment protocols involving injection of 0.2-0.5 mL per quadrant 1

The American College of Periodontology recommends that PRP should not be used for cosmetic breast augmentation due to the lack of supporting research, standardized protocols, and volumizing capability 1
The International Society on Thrombosis and Haemostasis (ISTH) guidelines suggest that more rigorous clinical trials with standardized protocols would be needed before PRP could be considered for breast augmentation 2
Standardized protocols for PRP preparation are needed, including reporting the purity of PRP preparations and platelet activation status, to improve outcomes 2
A new classification system has been proposed to account for variables like leukocyte content, red blood cell content, activation method, and platelet concentration, with guidelines recommending reporting the activation procedure, if used 2
FDA-approved options for breast augmentation include silicone implants, saline implants, and autologous fat transfer, which have more established protocols and outcomes 1
Emerging research is exploring combined approaches such as PRP with nanofat or hyaluronic acid for various aesthetic applications, but these have not been validated for breast augmentation 1
PRP is considered appropriate for general wound healing according to international guidelines, such as those from the Journal of Thrombosis and Haemostasis 2