Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 11/26/2025

Management of Gum Swelling with Chlorhexidine Mouthwash

Introduction to Chlorhexidine Mouthwash

  • The American Dental Association recommends using chlorhexidine mouthwash as an adjunct to mechanical oral hygiene for reducing gingivitis and plaque, with high-quality evidence supporting its effectiveness for up to 6 months 3

Concurrent Measures for Oral Hygiene

  • Patients should brush teeth at least twice daily with a soft-bristled toothbrush using gentle technique, as recommended by the American Dental Association 3
  • The American Dental Association suggests flossing at least once daily with waxed floss to minimize gingival trauma, as part of a comprehensive oral hygiene routine 4

Important Considerations for Chlorhexidine Use

  • The National Comprehensive Cancer Network advises against using chlorhexidine mouthwash to prevent oral mucositis in head and neck cancer radiation patients, due to potential adverse effects 1, 2
  • The American Cancer Society recommends maintaining adequate hydration throughout the day to help reduce the risk of oral complications, including those associated with chlorhexidine use 5