Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 6/26/2025

Hair Loss Associated with Mycophenolate Mofetil

Introduction to Mycophenolate Mofetil Side Effects

  • The most commonly reported side effects of mycophenolate mofetil include gastrointestinal symptoms, headache, increased risk of infections, and mild side effects such as backache, abdominal distension, and anorexia, according to the American Society of Transplantation 1

Hair Loss Management

  • When managing hair loss in patients taking mycophenolate mofetil, it is essential to rule out other causes by checking thyroid function, iron stores, vitamin D, and zinc levels, as recommended by the American Academy of Dermatology 2
  • Treatment options for hair loss include gentle hair care practices, topical minoxidil 5% to stimulate hair regrowth, and biotin supplementation, although evidence for efficacy is limited, as suggested by the National Institute of Health 2

Medication Adjustments

  • Medication adjustments, such as dose reduction or switching to an alternative immunosuppressant, may be necessary in severe cases of hair loss, and should be done in consultation with the prescribing physician, according to the American College of Rheumatology 2