Montelukast and Blood Pressure: Clinical Implications

Evidence from Hypertension Guidelines

• The International Society of Hypertension's 2020 guidelines state that NSAIDs can increase blood pressure by 3/1 mmHg with nonselective NSAIDs 1
• The International Society of Hypertension's 2020 guidelines report that combined oral contraceptive pills can increase blood pressure by 6/3 mmHg with high-dose estrogen 1
• The International Society of Hypertension's 2020 guidelines indicate that antidepressants, particularly SNRIs and tricyclics, can increase blood pressure 1
• The International Society of Hypertension's 2020 guidelines note that acetaminophen can increase blood pressure with almost daily use 1
• The International Society of Hypertension's 2020 guidelines list other medications, such as steroids, sympathomimetics, and antimigraine serotonergics, that can increase blood pressure 1
• The International Society of Hypertension's 2020 guidelines state that herbal substances, including alcohol, ma-huang, high-dose ginseng, and licorice, can increase blood pressure 1
• Montelukast is not included in the list of medications known to increase blood pressure according to the International Society of Hypertension's 2020 guidelines 3

Conclusion

• The International Society of Hypertension's guidelines conclude that montelukast is not recognized as a medication that typically increases blood pressure 1, 2, 3