Ibuprofen Safety and Efficacy

Patient Monitoring and Precautions

Patients at high risk (over 60 years, history of peptic ulcer, significant alcohol consumption) should be monitored for gastrointestinal risks 1, 2
Ibuprofen should be stopped in case of gastrointestinal bleeding or peptic ulcer 2
Caution is advised in patients at high risk of renal problems (over 60 years, compromised hydration status, interstitial nephritis) 2
Ibuprofen should be stopped if urea or creatinine doubles or if hypertension develops or worsens 2
Patients with a history of cardiovascular disease should be treated with caution 2

In children, the recommended dose is 10 mg/kg every 8 hours 3
For patients with cancer, ibuprofen can be used at doses of 400 mg every 4 to 6 hours (maximum 3200 mg/day) 1, 4