Vaginal Misoprostol Administration Guidelines

Dosing and Administration

• The American College of Obstetricians and Gynecologists recommends that additional symptoms, such as increased postprocedure cramping, may occur, particularly with higher doses or in nulliparous patients 1

Monitoring and Safety

• The American College of Obstetricians and Gynecologists suggests that continuous monitoring is recommended from 30 minutes to 2 hours after administration to assess for uterine hyperstimulation and fetal heart rate changes, with a moderate strength of evidence 2