Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 8/23/2025

Status Epilepticus Management with Sodium Valproate

Dosing Guidelines

  • IV loading doses of 20-30 mg/kg have been used effectively for status epilepticus, with infusion rates of up to 10 mg/kg/min reported as safe and well-tolerated, according to the American College of Emergency Physicians 1, 2
  • Higher doses of 30 mg/kg IV have shown 88% efficacy in controlling seizures within 20 minutes, as recommended by the American College of Emergency Physicians 3