Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 9/25/2025

Seizure Risk and Management in Pregnant Patients with Epilepsy

Introduction to Seizure Risk

  • The American Heart Association guidelines recognize that seizures in pregnant individuals constitute a medical emergency requiring EMS activation 1

Mechanisms and Management

  • Metabolic disturbances during labor (including hypoglycemia, electrolyte imbalances, and hypoxia) can precipitate seizures 1
  • The American Academy of Neurology emphasizes that seizure control is paramount for reducing maternal and fetal morbidity and mortality 2, 3

Labor and Delivery Planning

  • The American College of Obstetricians and Gynecologists recommends planning for specialized care during labor and delivery with appropriate monitoring 2
  • Continuous supervision is essential to ensure patient safety and rapid intervention if seizures occur 4
  • Have emergency protocols in place, as seizures lasting >5 minutes require immediate medical intervention with anticonvulsant medications 1

Immediate Seizure Management

  • Activate EMS immediately for seizures in pregnant individuals, as this is a specified emergency indication 1
  • Minimize injury risk by helping the patient to their side in the recovery position and clearing the area 1
  • Stay with the patient and do not restrain them or place anything in their mouth 1
  • Monitor for seizure duration, as seizures lasting >5 minutes represent status epilepticus requiring urgent intervention 1

Critical Management Principles

  • Never discontinue antiepileptic drugs during pregnancy or labor due to concerns about fetal effects, as breakthrough seizures carry catastrophic risks 2, 3

Risk-Benefit Balance

  • The risks of uncontrolled seizures during pregnancy and labor outweigh potential medication risks 2, 3
  • Women with epilepsy have approximately a one-third chance of experiencing increased seizures during pregnancy overall 2

REFERENCES

2

Management of Epilepsy in Pregnancy [LINK]

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

3

Lacosamide in Pregnancy: Management for Women with Controlled Seizures [LINK]

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

4