Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

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Last Updated: 7/9/2025

Weight Loss and Muscle Gain Guidelines

Introduction to Weight Loss

  • The American College of Cardiology recommends creating a moderate caloric deficit of 500-750 kcal/day for weight loss, which can lead to a weight loss of 5 lbs/month or approximately 1.25 lbs/week 1, 2
  • Daily caloric intake should be 1200-1500 calories for women and 1500-1800 calories for men, with a focus on complex carbohydrates and simple ingredients 1, 2, 3
  • Very low-calorie diets (<800 kcal/day) should be avoided except in limited medical circumstances 1

Nutrition Recommendations

  • A daily protein intake of at least 1g/kg body weight is recommended to preserve muscle mass during weight loss, and protein should be included at each meal for satiety 4, 2
  • Emphasize whole grains, such as brown rice, quinoa, barley, and oats, and include starchy vegetables like sweet potatoes and winter squash 3, 5
  • Choose whole fruits rather than juices, and include lean meats, fish, and plant proteins like lentils, beans, and tofu 3
  • Use olive oil, avocado oil, or coconut oil for cooking, and avoid processed foods containing seed oils like canola, corn, and soybean 3
  • Drink at least 64 oz of water daily, and avoid sugary beverages and limit alcohol consumption 3
  • Avoiding liquid calories (sodas, juices, alcohol) is recommended for weight loss 2

Aerobic Exercise Recommendations

  • The American Heart Association recommends aerobic exercise for ≥5 days/week, with an intensity of 55-90% maximum heart rate or 40-80% VO₂ max, and a duration of 30-60 minutes per session 6, 7
  • Accumulate 150-300 minutes of moderate-intensity activity weekly, and aim for 10,000+ steps daily 2, 3
  • For long-term weight maintenance, increasing aerobic exercise to 200-300 minutes weekly is recommended 8

Resistance Training Recommendations

  • The American Heart Association recommends resistance training 2-3 days/week, with an intensity of 50-80% of 1-repetition maximum (1-RM), and a volume of 1-3 sets of 8-15 repetitions per exercise 6
  • Targeting major muscle groups, such as leg extensions, leg curls, leg press, bench press, lateral pulldowns, biceps curl, and triceps extension, is recommended 6
  • High-intensity interval training may be particularly effective for increasing lean mass while decreasing body fat 8

Special Considerations

  • Older adults should prioritize resistance training to prevent sarcopenia 4
  • Individuals with cardiovascular disease should start with lower intensity and gradually progress 6
  • Individuals with obesity may benefit from starting with resistance training before formal aerobic exercise 9

Meal Planning and Portion Control

  • Weigh foods after cooking for accurate portion control, and track food intake using a food diary or app 2
  • Plan meals in advance, and avoid underestimating portion sizes, drinking calories, skipping meals, and using too much oil in cooking 2
  • Sample meal plans include:

    Meal Calories Food
    Breakfast 280 1/2 cup cooked steel-cut oats, 1 tbsp honey, 1/4 cup blueberries, 1 tbsp ground flaxseed
    Lunch 380 3 oz grilled chicken breast, 1 cup cooked brown rice, 1 cup steamed broccoli, 1 tsp olive oil
    Dinner 390 3 oz baked salmon, 1 cup cooked quinoa, 1 cup roasted Brussels sprouts, 1 tsp olive oil
    Snack 250 1 medium apple with 1 tbsp natural peanut butter, and 1 cup cucumber slices with 2 tbsp hummus

    2

Common Mistakes to Avoid

  • Excessive caloric restriction leading to muscle loss
  • Focusing only on aerobic exercise without resistance training
  • Inadequate protein intake during weight loss
  • Setting unrealistic expectations for rate of weight loss
  • Neglecting long-term maintenance strategies 1, 2, 4, 6, 7, 8, 9

REFERENCES

9

exercise programs for cancer-related fatigue: evidence and clinical guidelines. [LINK]

Journal of the National Comprehensive Cancer Network : JNCCN, 2010