Plasmapheresis Duration for Suspected TTP

Special Considerations

• For patients with lupus nephritis and suspected TTP, the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines recommend daily plasma exchange for 14 days or until anti-GBM antibodies are undetectable 2, 1
• In children with suspected TTP, it may be reasonable to defer TPE for 24-48 hours until ADAMTS13 results are available due to lower incidence of TTP and higher procedural risks 1

Monitoring and Complications

• Failing to monitor for TPE complications, which can include hemodynamic shifts, coagulation disorders, electrolyte imbalances, and line-related bacteremia, is a common pitfall 3