Management of Lower Urinary Tract Symptoms

Introduction to Alpha-Blockers

• The American Urological Association (AUA) notes that alpha-blockers, including alfuzosin, can cause ejaculatory problems as a primary adverse event 1

Mechanism of Action and Effects on Ejaculation

• Alpha-blockers like alfuzosin work by antagonizing alpha1-adrenoreceptors, producing the opposite effect of what would be needed to improve bladder neck closure, and can potentially worsen ejaculatory function 1

Comparison of Alpha-Blockers

• Alfuzosin has a lower risk of ejaculatory dysfunction than tamsulosin, but it still does not improve bladder neck closure 1

Clinical Guidelines and Recommendations

• The American Urological Association (AUA) guidelines state that alpha-blockers are not indicated for improving antegrade ejaculation, and can cause ejaculatory problems as a primary adverse event 1