Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 10/23/2025

Hysterectomy and Depression Risk

  • Hysterectomy is associated with an increased risk of depression, but the relationship is complex and depends heavily on pre-existing psychological factors, hormonal changes, and the clinical context in which the surgery is performed 1, 2, 3
  • The interdisciplinary team should be aware of the possible psychological effects of hysterectomy, including depression, loss of sexual pleasure and future childbearing 1, 2, 3

Evidence from Guidelines

  • The American College of Radiology acknowledges that even with bilateral ovarian conservation, hysterectomy alone is associated with elevated risk of subsequent mood disorders 4

Psychosocial Support

  • Psychologists should be included in the interdisciplinary team of caregivers, with counseling offered to both the affected woman and her partner 1, 2, 3
  • Extensive education about the surgery and its implications should be provided 1, 2, 3