Caution with Ibuprofen Use in Lupus Patients

Alternative Treatment Options for SLE Patients

The American College of Rheumatology recommends hydroxychloroquine as the cornerstone of therapy for all SLE patients, serving as the backbone of treatment 1
For pain management in SLE patients, low-dose glucocorticoids are preferred over NSAIDs for acute flares 1
Methotrexate is recommended for skin and joint manifestations in SLE patients 1
Azathioprine is preferred for maintenance therapy in SLE patients 1
Mycophenolate mofetil is recommended for renal and non-renal manifestations in SLE patients 1

The American College of Rheumatology recommends continuing hydroxychloroquine, sulfasalazine, and methotrexate through surgery for SLE patients 2
For non-severe SLE, mycophenolate mofetil, azathioprine, cyclosporine, and tacrolimus should be withheld 1 week prior to surgery 2
For severe SLE, these medications should be continued through surgery to prevent flares 2

When ibuprofen is necessary for SLE patients, the lowest effective dose should be used for the shortest duration possible 1