Side Effects of Vyvanse (Lisdexamfetamine)
Common Side Effects
- Headaches are commonly reported across all age groups 1, 2
- Increased heart rate and blood pressure occur in most patients, though effects are typically small at the group level 1, 2
- These cardiovascular changes may be clinically significant in patients with preexisting heart disease 2
- Clinical guidelines recommend monitoring pulse and blood pressure regularly during treatment 2
Weight and Growth Effects in Pediatric Patients
- Weight loss and growth suppression represent clinically significant concerns requiring careful monitoring 1, 2
- These effects appear dose-related and require ongoing monitoring of height and weight 2
Psychiatric Effects
- Contrary to earlier concerns, recent evidence suggests psychostimulants may actually decrease suicidal events in ADHD patients rather than increase them 1
Special Population Considerations
Pregnancy and Lactation
- Possible small increased risk for preterm birth when use continues in second half of pregnancy (aRR 1.30; 95% CI 1.10-1.55) 3
- Women should not breastfeed while taking Vyvanse; infants should be monitored for irritability, insomnia, and feeding difficulties if exposure occurs 3
Clinical Monitoring Requirements
- Regular monitoring should include pulse and blood pressure at each visit 2
- Assessment for emergence of psychiatric symptoms 2