Lisdexamfetamine Formulation and Administration

Available Formulations and Pharmacokinetics

• The American College of Obstetricians and Gynecologists notes that Vyvanse is only available as oral capsules for once-daily administration, with dosing starting at 20-30 mg in the morning and titrating by 10 mg weekly to a maximum of 70 mg daily 1, 2, 3, 4

Clinical Considerations

• The capsule formulation is specifically designed as a prodrug that requires enzymatic hydrolysis in the blood to convert the inactive lisdexamfetamine to its active form, d-amphetamine, with a mechanism of action that is fundamental to the drug's efficacy 1, 2, 3, 4