Cefepime Administration and Safety Considerations

Administration Considerations

• Extended or continuous infusions may be beneficial for infections due to bacteria with high MICs to increase probability of achieving pharmacokinetic/pharmacodynamic targets 1
• For serious infections such as bacteremia, infective endocarditis, and pneumonia, higher doses within the recommended range should be considered 2, 3

Safety Considerations

• Cefepime has relatively high pro-convulsive activity compared to other beta-lactams (160 on a relative scale where penicillin G = 100) 1