Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 9/30/2025

Cardiovascular Disease Risk Assessment with PREVENT

Comparison with European Risk Tools

  • The European guidelines use the SCORE2 and SCORE2-OP calculators, which predict fatal and nonfatal CVD events, but have different age-specific risk thresholds and geographic calibration, as noted by the American College of Cardiology 1
  • SCORE2 was developed from 45 European cohorts and calibrated to four geographic risk regions, with age-specific thresholds that differ substantially from American guidelines, according to the American College of Cardiology 1
  • The European approach uses lower percentage thresholds for defining high risk compared to US guidelines, as reported by the American College of Cardiology 1