Oral Micronized Progesterone: Formulation, Contraindications, and Dosing Guidelines

Formulation Details

• The capsule formulation of oral micronized progesterone contains peanut oil as a critical inactive ingredient, which serves as the excipient for the micronized hormone. 1

Contraindications & Alternatives

• Patients with a history of severe peanut allergy (anaphylaxis) should be excluded from receiving oral micronized progesterone capsules because of the peanut‑oil excipient. 1
• For individuals with peanut allergy, vaginal gel formulations of micronized progesterone— which do not contain peanut oil—provide a safe alternative route of administration. 1

Hormone Replacement Therapy (HRT) Dosing

• In HRT regimens, oral micronized progesterone is typically prescribed at 100 mg–200 mg once daily for 12–14 days each month (sequential schedule) or 100 mg once daily for 25 days each month (continuous schedule). 3