Clindamycin Use in Patients with Chronic Kidney Disease

Monitoring Considerations

• The Kidney Disease: Improving Global Outcomes (KDIGO) guidelines recommend monitoring eGFR and electrolytes at transitions of care and during acute illness for patients with CKD taking clindamycin 1

Pharmacokinetic Principles in Renal Impairment

• Unlike aminoglycosides or fluoroquinolones, clindamycin's predominantly hepatic metabolism via CYP3A4 and CYP3A5 makes it one of the safest antibiotics for use across all stages of CKD without adjustment, as opposed to drugs that require interval extension in renal impairment 2