Boron Supplementation and SHBG Reduction

Clinical Evidence and Guidelines

• The European Association of Urology and American Academy of Family Physicians identify primary factors that decrease SHBG, but boron is not mentioned in clinical guidelines as a factor that lowers SHBG 1
• The absence of long-term data beyond one week is a major caveat, including whether SHBG reduction persists beyond 7 days 1
• The body may develop compensatory mechanisms over time, and there may be safety concerns with chronic suppression of SHBG 2

Monitoring and Safety Considerations

• Any intervention that lowers SHBG should be monitored for free and total testosterone levels 1
• Monitoring for symptoms of androgen excess or deficiency is recommended when using interventions that lower SHBG 1
• Bone health markers should be monitored if SHBG-lowering interventions are used chronically 3