Safe Co-Administration of Chlorzoxazone and Escitalopram

Clinical Management Recommendations

• Standard monitoring for SSRI side effects is sufficient when using the combination of chlorzoxazone and escitalopram, as recommended by the American Academy of Pediatrics 1
• There are no documented additive CNS depression effects between chlorzoxazone and escitalopram that would require special precautions, according to clinical guidelines 2

QT Interval Considerations

• The European Society of Cardiology notes that escitalopram can potentially prolong QT interval, and monitoring is recommended if the patient is taking other QT-prolonging medications or has risk factors for QT prolongation 3
• The American Academy of Pediatrics recommends considering monitoring for QT prolongation when prescribing escitalopram, especially if the patient is taking other QT-prolonging medications or has risk factors for QT prolongation 4