Fluticasone Use During Pregnancy

Safety Profile and Evidence

The European Respiratory Society recommends that inhaled corticosteroids, including fluticasone, are not associated with increased risk of major congenital malformations, intrauterine growth restriction, preterm delivery, or low birth weight at usual therapeutic doses 1, 2
The European Respiratory Society/Thoracic Society of Australia and New Zealand designates fluticasone as "compatible" for use during pregnancy 1, 2
A meta-analysis confirmed that intranasal corticosteroids during pregnancy do not increase risks of major malformations, preterm delivery, low birth weight, or pregnancy-induced hypertension 3, 4

The European Respiratory Society recommends continuing fluticasone if the patient was well-controlled on it pre-pregnancy 1, 2
The European Respiratory Society recommends using the lowest dose necessary to maintain asthma control 1, 2
The European Respiratory Society suggests that while budesonide has more extensive pregnancy safety data and is technically preferred when initiating therapy, switching from fluticasone to budesonide is unnecessary if asthma is already well-controlled 1, 2
The Rhinology society recommends that all modern intranasal corticosteroids including fluticasone propionate and fluticasone furoate are safe at recommended doses 5, 6
The Journal of Allergy and Clinical Immunology suggests that intranasal fluticasone has reassuring safety data with accumulated evidence supporting its use 3, 4

The European Respiratory Society recommends that if a patient is already on fluticasone pre-pregnancy with good control, the current regimen should be continued and the dose optimized to the lowest effective level 1, 2
The European Respiratory Society recommends monitoring asthma/rhinitis control throughout pregnancy 1, 2
The Rhinology society recommends that if initiating therapy during pregnancy, budesonide, fluticasone, or mometasone are all acceptable first-line options for intranasal use 5, 6

The European Respiratory Society recommends that fluticasone is compatible with breastfeeding, as systemic absorption from inhaled or intranasal routes is minimal 1, 2