Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 11/18/2025

Evaluation of White Blood Cells in Urine During Menstruation

Diagnostic Approach

  • The Centers for Disease Control and Prevention recommends evaluating for pelvic inflammatory disease (PID) if there is uterine/adnexal tenderness or cervical motion tenderness in patients with white blood cells in urine during menstruation 1, 2
  • The presence of white blood cells on saline microscopy of vaginal secretions supports PID diagnosis, according to the Centers for Disease Control and Prevention 1, 2
  • The Centers for Disease Control and Prevention suggests testing for N. gonorrhoeae and C. trachomatis with nucleic acid amplification testing in patients with symptoms of PID 3, 4

REFERENCES

2

Diagnostic Approach to Vaginal Infections with Moderate Polymorphonuclear WBCs [LINK]

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025

4

Diagnostic Approach and Treatment for Pelvic Inflammatory Disease (PID) [LINK]

Praxis Medical Insights: Practical Summaries of Clinical Guidelines, 2025