Voriconazole Treatment for Serious Fungal Infections

Treatment Duration and Dosing

The treatment duration for invasive aspergillosis should continue until resolution or stabilization of all clinical and radiographic manifestations, as recommended by the Infectious Diseases Society of America 1
For candidemia in non-neutropenic patients, treatment duration should be at least 14 days following resolution of symptoms or following last positive culture, whichever is longer, according to the Infectious Diseases Society of America 2
The typical treatment course for esophageal candidiasis is 14-21 days until clinical improvement is seen, as suggested by the Infectious Diseases Society of America 3
Voriconazole is a preferred agent for CNS infections, such as aspergillosis and candidiasis, due to its good CNS penetration, as recommended by the Infectious Diseases Society of America 3, 4
Follow-up blood cultures should be obtained for all patients with candidemia to ensure clearance, as recommended by the Infectious Diseases Society of America 2

For patients with CNS infections, be aware of drug interactions, particularly with anticonvulsants, as warned by the Infectious Diseases Society of America 4