Pneumococcal Vaccination with PCV20 in HIV Patients with Prior PCV13 Vaccination

Recommendations for HIV Patients with Prior PCV13 Vaccination

• The Advisory Committee on Immunization Practices (ACIP) recommends that adults with immunocompromising conditions like HIV who previously received PCV13 only should receive a single dose of PCV20 at least 1 year after the PCV13 dose 1, 2
• Adults with HIV infection who previously received only PCV13 are recommended to receive either a single dose of PCV20 ≥1 year after the PCV13 dose or a single dose of PPSV23 at a ≥8 week interval after the PCV13 dose 1, 3
• If PCV20 is used in place of any dose of PPSV23, the pneumococcal vaccination series is considered complete and no additional pneumococcal vaccines are needed 2, 4

Rationale for PCV20 After PCV13 in Immunocompromised Patients

• Repeat doses of conjugate pneumococcal vaccines have been demonstrated to be modestly immunogenic in adults with immunocompromising conditions 1, 2
• PCV20 provides broader serotype coverage than PCV13 alone, offering protection against 7 additional serotypes (8, 10A, 11A, 12F, 15B, 22F, and 33F) 4

Important Clinical Considerations

• If the patient has received both PCV13 and PPSV23 previously, PCV20 would be recommended ≥5 years after the last pneumococcal vaccine dose 5
• Review the pneumococcal vaccine recommendations again when the person turns age 65 years, as additional doses may be recommended at that time 1, 2