Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 8/24/2025

Troubleshooting a Non-Functioning PICC Line

Initial Assessment and Management

  • When a PICC line is not functioning properly, a systematic approach should be followed to restore function, with guidewire exchange being the appropriate intervention if the catheter remains non-functional despite troubleshooting measures, as recommended by the American College of Physicians 1
  • Assess for mechanical causes of occlusion such as kinking of the external portion, clamps left in closed position, or dislodgement of the catheter, according to Clinical Nutrition guidelines 2
  • Check for potential migration of the catheter by examining the external length marking and comparing to documentation from insertion, as suggested by the Annals of Internal Medicine 1
  • Attempt to aspirate blood and flush with normal saline using a 10 mL syringe or larger to avoid excessive pressure that could damage the catheter, as recommended by Clinical Nutrition 2
  • Position the patient in different positions (e.g., raising or lowering the arm) to attempt to restore function, according to the Journal of the American College of Radiology 3

Prevention of Future Complications

  • Use normal saline rather than heparin to maintain catheter patency and prevent lumen occlusion, as recommended by the American College of Physicians 1
  • Ensure proper dressing care with clear, transparent dressings that permit site examination, according to the Annals of Internal Medicine 1
  • Avoid using the PICC for infusion of radiological contrast medium during CT or MR unless it is specifically certified as "pressure injectable", as suggested by Clinical Nutrition 2
  • Proper stabilization of the catheter is essential to prevent dislocation, with manufactured catheter stabilization devices preferred over stitches, according to Clinical Nutrition 2

Common Pitfalls to Avoid

  • Never use syringes smaller than 10 mL for flushing to avoid excessive pressure that could damage the catheter, as recommended by Clinical Nutrition 2
  • Never forcefully flush a catheter that is meeting resistance, as this could lead to catheter rupture, according to Clinical Nutrition 2