Diagnostic Accuracy of PCR and Line Probe Assay for Genital Tuberculosis

Molecular Testing Methods for Genital Tuberculosis

The Centers for Disease Control and Prevention recommends rapid molecular drug susceptibility testing for detecting rifampin resistance, with sensitivity and specificity of >97% for respiratory specimens 1
Line probe assays and molecular beacon tests have not been sufficiently validated for use on specimens other than respiratory specimens, according to the Clinical Infectious Diseases guidelines 1
The FDA has only approved one molecular beacon-based method (Xpert MTB/RIF) for tuberculosis diagnosis in respiratory specimens, as stated by the Clinical Infectious Diseases guidelines 1

Rapid molecular drug susceptibility testing should be used for subgroups in which drug resistance is more likely, as recommended by the Clinical Infectious Diseases guidelines 1