Acotiamide Dosing for Functional Dyspepsia

Clinical Context and Positioning

The British Society of Gastroenterology guidelines note that prokinetics like acotiamide are well-tolerated options, though the quality of evidence is rated as low with a weak recommendation, for patients with postprandial distress syndrome characterized by postprandial fullness, early satiation, and upper abdominal bloating 1
Acotiamide is positioned as a first-line prokinetic agent for functional dyspepsia, particularly for patients with postprandial distress syndrome, with benefits for PDS symptoms, according to the British Society of Gastroenterology 1

The 100 mg TID dose achieves therapeutic effects on gastric accommodation and gastric emptying in functional dyspepsia patients, through dual mechanisms: muscarinic receptor antagonism and acetylcholinesterase inhibition, and does not affect gastric emptying in healthy volunteers [@11@]