Levofloxacino Administration and Dosage

Presentations and Availability

• The levofloxacino is available in oral tablets (250 mg, 500 mg, 750 mg) and as an aqueous solution (500 mg in vials) for intravenous administration, according to the Centers for Disease Control and Prevention (CDC) 1, 2, 3
• The solution for intravenous administration is available in vials of 500 mg, as recommended by the CDC 3

Dosage and Administration

• The standard dose for adults is 500-1000 mg once daily, depending on the infection, as recommended by the American Thoracic Society 2, 3, 4
• The American College of Chest Physicians recommends that patients with renal impairment adjust their dosage accordingly 2, 3, 4

Safety and Precautions

• The CDC recommends that levofloxacino be avoided during pregnancy due to potential teratogenic effects 3
• The use of fluoroquinolones, including levofloxacino, in children and adolescents is not approved for long-term use due to concerns about effects on bone and cartilage growth, as recommended by the CDC 3
• Patients should be advised to maintain adequate hydration to prevent the formation of highly concentrated urine, which can increase the risk of crystalluria, as recommended by the CDC 3