Fluvoxamine Dosing for Obsessive-Compulsive Disorder in Adults

Therapeutic Range and Duration

• The American Academy of Family Physicians notes that the effective dose range for fluvoxamine is 100-300 mg/day in clinical trials demonstrating efficacy 1

Discontinuation

• The Journal of the American Academy of Child and Adolescent Psychiatry reports that fluvoxamine has been associated with discontinuation syndrome, particularly given its shorter half-life compared to some other SSRIs 2

Clinical Considerations

• The American family physician advises to exercise caution with drug interactions, as fluvoxamine is a potent CYP1A2 inhibitor and moderate inhibitor of CYP2C19 and CYP3A4, and to avoid concomitant use with alprazolam or triazolam due to interaction risk 1
• The Journal of the American Academy of Child and Adolescent Psychiatry also notes that fluvoxamine is a potent CYP1A2 inhibitor and moderate inhibitor of CYP2C19 and CYP3A4, requiring caution with drug interactions 2