Clindamycin Dosing and Therapy Recommendations

Adult and Pediatric Dosing

For MRSA osteomyelitis in adults, a dose of 600 mg every 8 hours (intravenous or oral) is recommended, as per the Infectious Diseases Society of America guidelines 1
For babesiosis in adults (in combination with quinine), a dose of 300-600 mg every 6 hours intravenously or 600 mg every 8 hours orally is recommended, based on guidelines from the Infectious Diseases Society of America 2
For MRSA infections in stable pediatric patients, a dose of 10-13 mg/kg/dose IV every 6-8 hours (to administer 40 mg/kg/day) is recommended, according to the Infectious Diseases Society of America guidelines 1

For MRSA osteomyelitis, a minimum 8-week course of therapy is recommended, as per the Infectious Diseases Society of America guidelines 1
For babesiosis, 7-10 days of therapy is typically recommended, based on guidelines from the Infectious Diseases Society of America 2
For antibiotic prophylaxis in patients with renal failure on dialysis, 600 mg of clindamycin can be administered orally 1 hour before dental procedures, as recommended by the American Dental Association 3
Clindamycin can be used as an alternative for patients allergic to penicillin in certain clinical scenarios, according to the American Dental Association guidelines 3

For complicated intra-abdominal infections in pediatric patients, the recommended dose is 20-40 mg/kg/day IV divided every 6-8 hours 4

The duration of therapy for complicated intra-abdominal infections with adequate source control is 4-7 days 5