Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 8/29/2025

Psychotic Disorders

Introduction to Psychotic Disorders

  • The American Academy of Child and Adolescent Psychiatry suggests that primary psychotic disorders include schizophrenia, delusional disorder, bipolar disorder with psychotic features, and depression with psychotic features, each characterized by distinct symptom patterns and requiring different treatment approaches 1, 2

Classification of Schizophrenia

  • The American Academy of Child and Adolescent Psychiatry classifies schizophrenia into several subtypes, including paranoid type (dominated by delusions), disorganized type (hebephrenic), catatonic type, undifferentiated type, and residual type 3, 4

Symptomatology of Psychotic Disorders

  • The American Academy of Child and Adolescent Psychiatry notes that positive symptoms of psychotic disorders include hallucinations, delusions, and thought disorders, which increase linearly with age and are more common in patients with an IQ above 85 3, 4
  • The American Academy of Child and Adolescent Psychiatry also identifies negative symptoms, including affective flattening, energy loss, and social withdrawal, which are often associated with brain damage 3, 4

Secondary Psychoses

  • The American College of Radiology indicates that substance-induced psychoses can be caused by alcohol, cocaine, amphetamines, cannabis, and other substances, triggering psychotic reactions in otherwise healthy individuals 1
  • The American Academy of Child and Adolescent Psychiatry states that medically induced psychoses can result from various medical conditions, including endocrine disorders, infections, and genetic or metabolic disorders 3, 4

Differential Diagnosis

  • The American College of Radiology differentiates psychoses from delirium, noting that psychoses typically maintain consciousness and attention 1, 2
  • The American Academy of Child and Adolescent Psychiatry recommends considering bipolar disorder with psychotic features in the differential diagnosis, especially for patients with affective symptoms 5

Treatment Approaches

  • The American College of Radiology suggests that primary psychoses require pharmacological management with antipsychotics, psychological therapy, and psychosocial interventions 1, 2
  • The American Academy of Child and Adolescent Psychiatry recommends a multimodal approach for treating delusional disorders, considering symptoms, comorbidities, and psychosocial stress factors 5