Endometrial Cancer Presentation and Diagnosis

Clinical Presentation

Approximately 90% of patients with endometrial carcinoma present with abnormal vaginal bleeding that is characteristically painless, particularly in postmenopausal women 1, 2, 3
The National Comprehensive Cancer Network recommends that any postmenopausal bleeding, regardless of pain presence or absence, warrants immediate evaluation with transvaginal ultrasound and endometrial biopsy 1, 2, 3
The painless nature of the bleeding often prompts patients to seek care early, when disease is still localized and treatable 1, 3

Early symptoms trigger patients to seek medical attention when disease is at an early, treatable stage, with approximately 75% of patients being diagnosed with stage I disease due to early investigation of painless bleeding 1, 2, 3, 4
The American College of Obstetricians and Gynecologists and the National Comprehensive Cancer Network suggest that early-stage disease has a favorable prognosis, with a 5-year survival rate exceeding 90% 2, 4