Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 8/28/2025

Lamotrigine and Cardiac Effects

Introduction to Lamotrigine's Cardiac Risks

  • Lamotrigine is classified as a mood stabilizer that has generally not been associated with severe arrhythmias, unlike some other psychotropic medications that have well-established cardiac risks, according to the European Heart Journal 1.

Management of Bradycardia

  • For symptomatic bradycardia that is unresponsive to medication discontinuation, temporary pacing may be considered in cases of persistent hemodynamically unstable bradycardia, as recommended by the Journal of the American College of Cardiology 2.