Vyvanse Dosage and Administration Guidelines for Pediatric Patients

Initial Dosing and Titration

The American College of Obstetricians and Gynecologists recommends a starting dose of 30 mg once daily in the morning for pediatric patients, including 12-year-old females 1
An alternative starting dose of 20 mg may be considered for patients who may be more sensitive to stimulant medications or have concerns about tolerability 1
The medication should be administered in the morning to minimize potential sleep disturbances 2
The maximum approved daily dose is 70 mg 1

The American Academy of Child and Adolescent Psychiatry recommends assessing target ADHD symptoms through parent and teacher reports during the initial titration phase 2
Weekly telephone contact can be maintained during dose adjustments 2
More frequent appointments are warranted if side effects emerge, comorbid psychiatric conditions are present, or adherence concerns arise 2
Monthly follow-up appointments are appropriate once symptoms are stabilized on a maintenance dose 2

If the maximum recommended dose (70 mg) does not provide adequate symptom control, consider switching to a different medication class rather than exceeding the maximum dose 2

The American Academy of Child and Adolescent Psychiatry recommends titrating lisdexamfetamine based on clinical response and tolerability, with dose adjustments in increments of 10 mg or 20 mg at approximately weekly intervals 3, 4

The American Academy of Child and Adolescent Psychiatry suggests monitoring vital signs, including blood pressure and pulse, as well as tracking height and weight regularly, as stimulants can affect growth 5
The American Academy of Child and Adolescent Psychiatry recommends assessing for common side effects, such as decreased appetite, insomnia, and headache, during treatment with lisdexamfetamine 5