Pharmacokinetic Considerations for Bispecific Antibodies

Target-Mediated Drug Disposition

• High concentrations of soluble target can significantly affect drug clearance through target-mediated drug disposition, and mechanistic PK models incorporating TMDD are necessary when doses are low, according to the European Medicines Agency 1, 2
• For antibodies binding to soluble antigens, target-mediated drug disposition can dramatically alter PK profiles, as stated by the National Institute of Health 1
• The American Society for Clinical Pharmacology and Therapeutics recommends using PK data to develop mechanistic models incorporating TMDD for accurate dose prediction 1, 2