Serious Side Effects of Donanemab Infusions

ARIA Risk Factors

• Patients with higher baseline amyloid burden, presence of microhemorrhages or superficial siderosis on baseline MRI, and cardiovascular risk factors are at increased risk of developing ARIA, according to the Alzheimer's and Dementia guidelines 1
• The American Academy of Neurology recommends considering APOE ε4 testing before treatment to assess ARIA risk, as APOE ε4 homozygote status is a significant risk factor, with higher risk of ARIA in these patients 1

Clinical Implications

• The Alzheimer's Association suggests that benefit-risk assessment should consider that clinical benefit may be reduced in patients with high tau burden, with careful patient selection and monitoring being essential, particularly for those with risk factors, as stated in the Alzheimer's and Dementia guidelines 1