Praxis Medical Insights

Est. 2024 • Clinical Guidelines Distilled

Made possible by volunteer editors from the University of Calgary & University of Alberta

Last Updated: 9/2/2025

Treatment of Dyshidrosis Eczema with Topical Corticosteroids

Selection of Topical Corticosteroid Potency

  • For mild dyshidrotic eczema, use mild-potency topical corticosteroids first 1
  • For severe or recalcitrant dyshidrotic eczema, potent topical corticosteroids may be necessary but should be used for limited periods only 2, 1

Application Method

  • Do not apply more frequently than recommended as this doesn't improve efficacy but increases risk of side effects 1

Duration of Treatment

  • Use topical corticosteroids for short courses to control flares 2
  • Very potent and potent categories should be used with caution for limited periods only 2

Monitoring and Side Effects

  • Risk of pituitary-adrenal axis suppression exists with extensive use, particularly in children 1
  • Monitor for signs of skin atrophy, telangiectasia, or striae 1

Adjunctive Therapies

  • Emollients should be used regularly as they provide a surface lipid film which retards evaporative water loss 1
  • For severe pruritus, sedating antihistamines may be useful as a short-term adjuvant during relapses 3
  • Non-sedating antihistamines have little to no value in treating dyshidrotic eczema 3
  • For cases with secondary bacterial infection, flucloxacillin is usually the most appropriate antibiotic 2

Treatment-Resistant Cases

  • Referral to a dermatologist if not responding to first-line management 1
  • PUVA (psoralen plus ultraviolet A) therapy may be considered for severe, treatment-resistant cases, though evidence from randomized controlled trials has not consistently demonstrated efficacy 4

Special Considerations

  • Avoid soap and detergents as they remove natural lipids from the skin surface 1
  • Use dispersible cream as a soap substitute to cleanse the skin 1
  • Keep nails short to minimize damage from scratching 1