Ibuprofen Dosage and Safety Guidelines

Dosing Recommendations

• For chronic non-bacterial osteitis, a daily dose of 1800 mg in divided doses is recommended 1
• Standard antipyretic dosing is 200-400 mg every 4-6 hours, with a maximum daily dose of 1200 mg 2

Safety Considerations

• The risk of GI complications increases with higher doses and prolonged use, and gastroprotection with proton pump inhibitors should be considered for chronic use with higher doses 3
• Patients with a history of GI bleeding, cardiovascular disease, or renal impairment may require dose adjustment or alternative therapy 3

Special Populations and Dosage

• When treating migraines, the dose should not exceed 2.4 g per day 4, 5